Star Dowites

ARSHAD JAHANGIR, MD, FACC

Scottsdale, AZ 85259

Tel: (480)-342-2214

PRESENT ACADEMIC RANK and POSITION:

Professor of Medicine

Consultant Cardiologist (Clinical Electrophysiology)

Director CardioGerontology Research Laboratory

Division of Cardiovascular Diseases

Mayo Clinic, Scottsdale-Phoenix, Arizona

Teaching/Examining Privileges in Molecular and Experimental Pharmacology

Mayo Graduate School

                                                                                                                                                     Mayo Clinic, Rochester, MN

1. POSITIONS, HONORS AND AWARDS

Professor of Medicine, Mayo Clinic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         2009-

      Member Scientific Study Section, Myocardial Ischemia and Metabolism, NIH                                                                                                                                            2010-2016 Vice Chair Special Population Section, ASCPT                                                                                                                                                                                                                                                                                                                                                                                          2010-2011      

Member Publications Committee American Society for Clinical Pharmacology and Therapeutics       2010-  

      Chair, Geriatric Section, American Society for Clinical Pharmacology and Therapeutics                                                                     2009-2010

      Member of the Fellowship Subcommittee of the Heart Rhythm Society                                                                                                                                                                                                                        2008-

Consultant Cardiologist, Mayo Clinic Arizona, Scottsdale, AZ                                                                                                                                                                                                                                                                                         2008-

Director, CardioGerontology Research Lab, Mayo Clinic Arizona, Scottsdale, AZ                                                                                                                                2008-

      Associate Professor of Medicine, Mayo Clinic                                                                                                                                                                                                                                                                                                                                                                                                          2003-2009

Consultant Cardiologist, Mayo Clinic, Rochester, MN                                                                                                                                                                                                                                                                                                                                                     2002-2008

Director, CardioGerontology Research Lab, Rochester, MN                                                                                                                                                                                                                                                                                                      2002-2008

Assistant Professor of Medicine, Mayo Clinic                                                                                                                                                                                                                                                                                                                                                                                                                             2001-2003

Senior Associate Consultant,        Mayo Clinic, Rochester, MN                                                                                                                                                                                                                                                                                                              1997-2002             

      Vice Chair Geriatric Section,        ASCPT                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2008-2009

William B Abrams Award in Geriatric Clinical Pharmacology                                                                                                                                                                                                                                                                                               2007

Marriott Mitochondrial Medicine Award, Mayo Clinic                                                                                                                                                                                                                                                                                                                                                           2008

Mayo Clinic Robert and Arlene Kogod Program on Aging Award                                                                                                                                                                                                                                                                      2005

Award for Research in Cardiology, Department of Medicine, Mayo Clinic                                                                                                                                                                                            2005

Medicine Innovation Development and Advancement System Award, Mayo Clinic                                                                                                                 2005

Clinical Research (CR75) Award, Mayo Foundation                                                                                                                                                                                                                                                                                                                                                       2002

Geriatric Cardiology Society Award in Basic Sciences                                                                                                                                                                                                                                                                                                                                                  2001

Clinical Research (CR) Award, Mayo Foundation                                                                                                                                                                                                                                                                                                                                                                                   2000

Clinical Research (CR20) Award, Mayo Foundation                                                                                                                                                                                                                                                                                                                                                                  1999

Karis Award, Saint Marys Hospital and Mayo Clinic                                                                                                                                                                                                                                                                                                                                                                               1998

Merit Scholarships in SSC and HSC Board Examinations

Honors with Distinctions throughout College (top 1%) and Medical School        (top 5%)                                                                                                         1978-1986

Associate Editor: Expert Review of Clinical Pharmacology                                                                                                                                                                                                                                                                                                                    2010-

Member Editorial Board Journal of Aging Research                                                                                                                                                                                                                                                                                                                                                                   2009-Associate Editor: Pharmacology & Therapeutics: Principles & Practice                                                                                                                                                                                                              2007-

Associate Editor: Mayo Clinic Cardiology Textbook                                                                                                                                                                                                                                                                                                                                                                    2007-

Member Editorial Board International Journal of Biomedical Science                                                                                                                                                                                                                           2006-

Medical Editor, Web Page North American Society of Pacing and Electrophysiology                                                                                                  1999-2000

Contributor to the ABIM Certification and Recertification Examination for Internal Medicine and   

Subspecialty Examination in Cardiovascular Diseases and Cardiac Electrophysiology

Diplomat American Board of Clinical Pharmacology      (2005), Diplomat American Board of Internal Medicine

   Cardiac Electrophysiology (1998, 2008) Cardiovascular Medicine    (1997, 2007) Internal Medicine           (1992) 

Reviewer for Research Grants                                                                              

NIH Myocardial Ischemia and Metabolism (MIM) Study Section (Chartered Member 2010-2016)    

NIH Myocardial Ischemia and Metabolism (MIM) Study Section (Adhoc: June 2009, June 2008, Oct 2007)                                            NIH Special Emphasis Panel Cardiac Remodeling, Aging and Vascular Function (July 2008)

NIH, National Heart, Lung and Blood Institute Program Project (P01) (Jan 2007)

NIH Cardiac Contractility, Hypertrophy, and Failure Study Section      (Adhoc: 2004)

Mayo Discovery Translation Program    (2006-Present), Mayo Foundation Scholar Award (2006)

Ministry of Health of the Czech Republic (2002), The Nemours Foundation, Florida (2000)   

Reviewer for Scientific Abstracts

Annual Scientific Sessions of the Heart Rhythm Society, American Heart Association, American

College of Cardiology, American Society for Clinical Pharmacology and Therapeutics.                                             

Reviewer for Scientific Journals

American Heart Journal, American Journal of Cardiology, American Journal of the Medical Sciences, American Journal of Physiology, Cardiovascular Research, Circulation, Circulation: Arrhythmia and Electrophysiology, Circulation Research, Clinical Cardiology, Clinical Pharmacology and Therapeutics, European Heart Journal, Heart Rhythm, International Journal of Biomedical Science, International Journal of Emergency Medicine, Journal of Aging Research, Journal of the American College of Cardiology, Journal of American Geriatric Society, Journal of Cardiovascular Electrophysiology, Journal of Cardiovascular Translational Research, Journal of Molecular and Cellular Cardiology, Mayo Clinic Proceedings, Mechanisms of Ageing and Development, Mitochondrion, Pflugers Archiv-European Journal of Physiology.

1. SELECTED PUBLICATIONS

1. Jahangir A, Terzic A, Kurachi Y: Intracellular acidification and ADP enhance Nicorandil induction of ATP-sensitive K+ channel current in cardiomyocytes. Cardiovasc Res 1994;28:831-5.
2. Yamada M, Jahangir A, Hosoya Y, Inanobe A, Katada T, Kurachi Y: Gk and brain Gactivate muscarinic K+ channel through the same mechanism. J Biol  Chem 1993;268:24551-4.
3. Terzic A, Jahangir A, Kurachi Y:HOE-234, a second generation K+channel opener, antagonizes the ATP dependent gating of cardiac ATP-sensitive K+ channels. J Pharmacol Exp Ther 1994;268:818-25.
4. Takahashi N, Morishige K, Jahangir A, Yamada M, Findlay I, Koyama H, Kurachi Y: Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. J Biol Chem 1994;269:23274-9.
5. Morishige K, Takahashi N, Jahangir A, Yamada M, Koyama H, Zanelli J, Kurachi Y: Molecular cloning and functional expression of a novel brain-specific inward rectifier K⁺ channel. FEBS lett 1994;346:251-6.
6. Terzic A, Jahangir A, Kurachi Y: Cardiac ATP-sensitive K+ channels: regulation by intracellular nucleotides and potassium channel opening drugs. Am J Physiol 1995;269:C525-45.
7. Lopez JR, Jahangir R, Jahangir A, Shen W, Terzic A: Potassium channel openers prevent K⁺-induced Ca²⁺ loading of cardiac cells: possible implications in cardioplegia. J Thorac Cardiovasc Surg 1996;112:820-31.
8. Jahangir A, Kolbert C, Edwards W, Mitchell P, Hall JF, Dumler JS, Persing DH.  Fatal Pancarditis associated with granulocytic ehrlichiosis in a 44-year-old man. Clinic Infect Dis 1998;27:1424-7.
9. Jahangir A, Stanton MSS, Hammill SC, Shen WK. Class I and III antiarrhythmic drugs: Practical considerations for safe, effective use. Hospital Formulary 1998;33:534-57.
10. Shen WK, Jahangir A, Beinborn D, Lohse C, Hodge DO, Rea RF, Hammill SC. Utility of a single-stage tilt testing in the adult. A randomized comparison study to head-up tilt. J Am Coll Cardiol 1999;33:985-90.
11. Jahangir A, Shen WK, Neubauer S, Ballard D, Hammill S, Hodge D, Lohse C, Gersh B, Hayes DL. Relation between mode of pacing and long-term survival in the very elderly. J Am Coll Cardiol 1999;33:1208-16.
12. Abraham MR, Jahangir A, Alekseev AE, Terzic A. Channelopathies associated with inward rectifier potassium channels. FASEB J 1999;13:1901-10.
13. Ozcan C, Holmuhamedov EL, Jahangir A, Terzic A. Diazoxide protects mitochondria from anoxic injury: Implications for myopreservation. J Thorac Cardiovasc Surg 2001;121:298-306
14. Ozcan C, Jahangir A, Friedman PA, Munger TM, Gersh BJ, Rea RF, Lloyd MA, Hodge DO, Hayes DL, Hammill SC, Shen WK.  Atrial Fibrillation:  Long-term survival after ablation of the atrioventricular node and implantation of permanent pace maker in patients with atrial fibrillation. N Engl J Med 2001;344:1043-51
15. Gumina RJ, Jahangir A, Gross GJ, Terzic A. Cardiprotection: emerging pharmacotherapy. Exp Opin Pharmacother 2001;2: 2001;2:739-52
16. Holmuhamedov EL, Ozcan C, Jahangir A, Terzic A. Rescue of Ca²⁺-inhibited oxidative phosphorylation in cardiac mitochondria by mitochondrial Ca²⁺ unloading. Mol Cell Biochem  2001;220:135-40.
17. Jahangir A, Ozcan C, Holmuhamedov EL, Terzic A. Increased vulnerability of senescent cardiac mitochondria to calcium loading. Mech Ageing Dev 2001;122:1073-86.
18. Jahangir A, Terzic A, Shen WK. Potassium channel openers: Therapeutic potential in Cardiology and Medicine.  Exp Opin Pharmacother 2001;2:1995-2010 .
19. Dzeja PP, Holmuhamedov EL, Ozcan C, Pucar D, Jahangir A, Terzic A. Mitochondria: Getaway for cytoprotection. Circ Res 2001;89:744-746.
20. Holmuhamedov EL, Lewis L, Bienengraeber M, Holmuhamedova M, Jahangir A, Terzic A. Suppression of human tumor cell proliferation through mitochondrial targeting. FASEB J 2002;16:1010-1016.
21. Ozcan C, Jahangir A, Friedman PA, Munger TM, Packer DL, Hodge DO, Hayes DL, Gersh BJ, Rea RF, Lloyd MA, Hammill SC, Shen WK. Effect of left ventricular function on long-term survival in patients with atrial fibrillation after atrioventricular node ablation. J Am Coll Cardiol 2002;40:105-110.
22. Jahangir A, Shen WK. Pacing in the elderly. Am Heart J 2003;146:750-753.
23. Liu X-K, Jahangir A, Terzic A, Friedman PA, Gersh BJ, Hammill SC, Shen WK. Age and gender-associated atrial electrophysiological and morphological changes: potential mechanisms underlying the higher risk of developing atrial fibrillation in the elderly and men. Am J Cardiol 2004;94:373-375.
24. Holmuhamedov EL, Jahangir A, Oberlin A, Komarov A, Colombini M, Terzic A. Potassium channel openers are uncoupling protonophores: implication in cardioprotection. FEBS lett 2004;568:167-170.
25. Liu XK, Yamada S, Kane GC, Alekseev AE, Hodgson DM, O'Coclain F, Jahangir A, Miki T, Seino S, Terzic A. Kir6.2 gene deletion predisposes to catecholamine-induced dysrhythmia. Diabetes 2004;53:S165-168
26. Vlietstra RE, Jahangir A, Shen WK. Choice of pacemakers in patients age 75 and older. VVI vs. DDD. Am J Geriat Cardiol 2005;14:35-38.
27. Jahangir A, Terzic A. KATP channel therapeutics at the bedside. J Mol Cell Cardiol 2005;39:99-112.
28. Jahangir A, Hammill SC. Parasympathetics and atrial fibrillation. J Cardiov Electrophysiol 2005;16:885-7.
29. Chen LY, Jahangir A, Decker WW, Smars PA, Wieling W, Hodge DO, Gersh BJ, Hammill SC, Shen WK. Score indices for predicting electrophysiologic outcomes in patients with unexplained syncope. J Intevent Card Electrophysiol 2005;14:99-105.
30. Jahangir A, Shen WK, Terzic A. Potassium channel openers: Novel therapeutics in Cardiovascular Medicine. Heart Physiology and Pathophysiology. N. Sperelakis, et al., Editors. San Diego: Academic Press, 2001. p. 1261
31. Jahangir A, Munger TM, Packer DL, Crijns H. Atrial fibrillation. In: Podrid, PJ; Kowey, PR; editors. Cardiac arrhythmia: mechanisms, diagnosis, and management. 2nd edition. Philadelphia: Lippincott Williams & Wilkins 2001. p. 457-499.
32. Jahangir A, Terzic A, Shen WK. Antiarrhythmic drugs and future direction In: Gussak I. Antzelevitch C. Hammill SC. Shen WK. Bjerregaard P, editor(s). Cardiac repolarization: bridging basic and clinical science Totowa: Humana Press; 2003. 387-404. Contemporary Cardiology.
33. Sengupta P, Khandheria BK, Korinek J, Wang J, Jahangir A,  Seward JB, Belohlavek M. Apex-to-base dispersion in regional timing of left ventricular shortening and lengthening. J Am Coll Cardiol 2006;47:163-72.
34. Bjerregaard P, Jahangir A, Gussak I. Targeted Therapy for Short QT Syndrome. Expert Opin Ther Targets 2006;10:393-400.
35. Sengupta PP, Belohlavek M,  Narula J, Korinek J,  Jahangir A,  Khandheria BK. Left Ventricular Structure And Function: Basic Science For Cardiac Imaging.  J Am Coll Cardiol 2006;48:1988-2001.
36. Olson TM, Alekseev AE, Liu X, Park S, Zingman LV, Bienengraeber M, Ballew JD, Jahangir A, Terzic A. Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum Mol Genet 2006;15:2185-2191.
37. Jahangir A, Zingman L, Terzic A. Essentials of Pharmacokinetics and Pharmacodynamics. In: Murphy JG, Lloyd MA, editors. Mayo Clinic cardiology: concise textbook. 3rd Edition. Rochester: Mayo Clinic Scientific Press : Informa Healthcare; 2007. p. 1189-1204.
38. Sengupta PP, Khandheria BK, Korinek J, Wang JW, Jahangir A, Yoshifuku S, Milosevic I, Belohlavek M. A Left ventricular isovolumic flow sequence during sinus and paced rhythms: New insights from use of high-resolution Doppler and ultrasonic digital particle imaging velocimetry J Am Coll Cardiol 2007;49:899-908.
39. Olson TM, Alekseev AE, Moreau C, Liu XK, Zingman LV, Miki T, Seino S, Asirvatham SJ, Jahangir A, Terzic A. K_ATP channel mutation confers risk for adrenergic atrial fibrillation originating from the vein of Marshall. Nat Clin Pract Cardiovasc Med 2007 2007; 4:110-116.
40.  Jahangir A, Bradley D, Shen WK. ICDs for secondary prevention of sudden death in the older-elderly. Eur Heart J 2007;28:1665-1667.
41. Jahangir A, Lee V, Friedman PA, Trusty JM, Hodge DO, Kopecky SL, Packer DL, Hammill SC, Shen WK, Gersh BJ. Long-term progression and outcomes with aging in patients with lone atrial fibrillation: A 30-year follow-up study. Circulation 2007 Jun 4; [Epub ahead of print].
42. Chen LY, Hodge D, Jahangir A, Ozcan C, Trusty J, Friedman P, Rea R, Bradley D, Brady P, Hammill S, Hayes D, Shen WK. Preserved left ventricular ejection fraction following atrioventricular nodal ablation and pacing for atrial fibrillation. J Cardiovasc Electphysiol 2007 . Oct 25; [Epub ahead of print].
43. Singh M, Rihal C, Roger V, Lennon R, Spertus J, Jahangir A, Holmes D. Comorbidity and Outcome after Percutaneous Coronary Interventions. Heart 2007;Oct 8; [Epub ahead of print].
44. Jahangir A, Sagar S, Terzic A. Aging and Cardioprotection. J Appl Physiol  2007; 103:2120-2128.
45. Preston CC, Oberlin AS, Holmuhamedov E, Sagar S, Syed RHK, Siddiqui S, Sreekumar S, Terzic A, Jahangir A. Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart. Mech Ageing Dev 2008;129:304-312.
46. Terzic A, Vivaudou M, Moreau C, Olson TM, Jahangir A, Zingman LV, Alekseev AE, Channelopathies of cardiac inwardly rectifying potassium channels. Electrical Disease of the Heart: Genetics, Mechanisms, Treatment, and Prevention. 2008. p. 207-217.
47. Cha YM, Friedman PA, Asirvatham SJ, Shen WK, Munger TM, Rea RF, Brady P, Jahangir A, Monahan KH, Gersh BJ, Hammill SC,  Packer DL. Catheter ablation for atrial fibrillation in patients with obesity. Circulation 2008;117:2583-2590.
48. Singh, M, Alexander K, Roger VL, Rihal CS, Whitson HE, Lerman A, Jahangir A, Nair KS. Frailty and its potential relevance to cardiovascular care. Mayo Clin Proc 2008;83:1146-1153.
49. Jahangir A, Sattiaraju S, Shen WK. Senescence and Arrhythmogenesis. In: Gussak I, Antzelevitch C. Electrical Disease of the Heart: Genetics, Mechanisms, Treatment, and Prevention. Springer-Verlag. 2008.
50. Sengupta PP, Tondato F, Khandheria BK, Belohlavek M, Jahangir A. Electromechanical activation sequence in normal heart. Heart Failure Clin 2008;4:303-314.
51. Jahangir A, Maria V. Pharmacology of Coronary artery Disease. Pharmacology & Therapeutics: Principles & Practice. Ed: Waldman and Terzic. 2008.
52. Liu X-K, Jahangir A, Shen WK. Dysrhythmias in Older Adults. in Principles of Geriatric Medicine and Gerontology, 6th edition. 2009.
53. Sun X, Hoage T, Bai P, Ding Y, Chen Z, Zhang R, Huang W, Jahangir A, Paw B, Li YG, Xu X. Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish. PLoS One 2009; 4:e6596. Epub 2009 Aug 12.
54. Jayachandran M, Preston CC, Hunter LW, Jahangir A, Owen WG, Korach KS, Miller VM. Loss of estrogen receptor β decreases mitochondrial energetic potential and increases thrombogenicity of platelets in aged female mice. AGE 2009; DOI 10.1007/s11357-009-9119-y PMID: 19908165.
55. Jahangir A, Murarka S. Progression of paroxysmal to persistent atrial fibrillation. Factors promoting the HATCH. J Am Coll Cardiol 2010;55:732-4. PMID: 20170809
56. Ara T, Maria V, Jahangir A. Use of Herbal Products and Potential Issues with Cardiovascular Diseases. J Am Coll Cardiol 2010;55:515-25. PMID: 20152556
57. Jahangir A, Maria V, Ara T. Use of Herbal Products and Potential Issues with Cardiovascular Diseases. Response to letter to editor. J Am Coll Cardiol 2010;56:903-909.
58. Sagar S, Shen WK, Asirvatham S, Cha Y, Espinosa R, Friedman P, Hodge DO, Munger TM, Porter CJ, Rea RF, Hayes DL, Jahangir A. The presence of antibodies not right ventricular apex pacing is associated with poor long-term outcomes in patients with isolated congenital atrio-ventricular block. Circulation 2010;121:1698-705. PMID: 20368525
59. 76. Deeds MC, Anderson JM, Armstrong AS, Gastineau DA, Hiddinga HJ, Jahangir A, Eberhardt NL, Kudva YC. Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models. Lab Anim. 2011 Apr 08. [Epub ahead of print]
60. Bhatia NL, Jahangir A, Pavlicek W, Scott LRP, Altemose GT, Srivathsan K. Reducing ionizing radiation associated with atrial fibrillation ablation: An ultrasound-guided approach. J A Fib 2011;2:822-826.
61. Mirza M, Caracciolo G, Khan U, Mori N, Saha SK, Srivathsan K, Altemose G, Scott L, Sengupta P, Jahangir A. Left atrial reservoir function predicts atrial fibrillation recurrence after catheter ablation: A two-dimensional speckle strain study. J Interv Card Electrophysiol. 2011 Mar 22. [Epub ahead of print]

2. RESEARCH SUPPORT

Ongoing Research Support

R01HL101240-01      National Heart Lung and Blood Institute / NIH                                                                         Jahangir, A   (PI)                2010-2014

Title: Mitochondrial Dysfunction and Susceptibility to Atrial Fibrillation in the Elderly                                                                  

R01HL089542                                        National Heart Lung and Blood Institute / NIH                                                                                             Jahangir, A   (PI)                2008-2012                      Title:   Human Senescence and Cardioprotection                                                                                                                                                                                                                                                                                                                                                                                

Angel and Paul Harvey Cardiovascular Research Endowment                                                                            Jahangir, A   (PI)                                                       2009-2012

             CardioGerontology Research Laboratory, Mayo Clinic Arizona                                                                                            

Marriott Discovery Translational Mitochondrial Medicine Award                                                                                                               Jahangir, A   (PI)                2008-2011

     Title: Mitochondria and Cardioprotection in the Aging Human Heart                   

Completed Research Support       

R01 AG 21201-03                                                                                                                                                                                                                                                                                                                                                                                                                                             Jahangir, A   (PI)                                             2002-2008

National Institute on Aging / NIH                                                                           

Title: Mitochondria and surgical myopreservation in the elderly.

Robert and Arlene Kogod Program on Aging Award                                                                                                                                                                                                             Jahangir, A  (PI)                                              2005-2007

Title: Changes in Gene Expression Underlying Increased Susceptibility of the Aging Heart to Injury.

AHA 02-30133N                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Jahangir, A  (PI)                                                 2002-2005

National Scientist Development Grant, American Heart Association

Title: Myopreservation of the senescent heart

Award for Research in Cardiology. Department of Medicine, Mayo Clinic                           Jahangir, A  (PI)                                  2005

Title: Altered Energetics and Ca²⁺ Handling in Aging Human Atria Underlies Increased Susceptibility to AF  

Medicine Innovation Development and Advancement System, Mayo Clinic                       Jahangir, A  (PI)                                              2005-2006

Title: Age-related Genomic and Proteomic Dynamics in Susceptibility of the Failing Human Heart to Injury.

CR75 Research Award, Mayo Foundation for Education and Research                              Jahangir, A  (PI)                                              2002-2004

Title: Aging and mitochondria: Protective role for a K_ATP channel

Geriatric Cardiology Society Award in Basic Sciences                                                                                                         Jahangir, A  (PI)                                                        2001-2002

Title: Aging and mitochondrial dysfunction

Clinical Research (CR) Award Mayo Foundation                                                                                                                                                                                                                                          Jahangir, A  (PI)                                                        2000-2002                               Title: Electrical activity in the metabolically compromised heart

Clinical Research (CR20) Award Mayo Foundation                                                                                                                                 Jahangir, A  (PI)                                              1999-2000

Title: Developmental changes in K_ATP channel expression and regulation in fetal, neonatal and adult heart.